Immune Modulation and Reconstitution of HIV-1-Specific Responses: Novel Approaches and Strategies

Authors: Burton, C. T.; Mela, C. M.; Rosignoli, G.; Westrop, S. J.; Gotch, F. M.; Imami, N.

Source: Current Medicinal Chemistry, Volume 13, Number 26, November 2006 , pp. 3203-3211(9)

Publisher: Bentham Science Publishers

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Abstract:

Efficacious protection for future generations from HIV-1 infection through the development of prophylactic vaccines is the best hope for the millions of individuals living with the threat of HIV-1 infection. Advances in the development of non-curative chemotherapy for those already infected have changed the course of the epidemic for those with access to the drugs. However in the ten years since the advent of highly active anti-retroviral therapy, the expectancy of curative chemotherapy has been quashed, and the constant need for a next generation of drugs is evident. As our understanding of HIV-1 pathogenesis increases, it is becoming apparent that novel approaches and strategies will be required to halt the global progression of HIV-1. Immune-based therapies are being considered in the context of effective antiretroviral therapy. Such immunebased therapy must allow the induction or regeneration of HIV-1-specific T-cell responses with the potential to control viremia and purge viral reservoirs. Studies of therapy substitution, treatment interruption, therapeutic vaccines and/or cytokines and/or hormones have been carried out and are briefly summarised in this review.

Keywords: HAART; HIV-1; Immune modulation; cytokines; immune reconstitution; immunisation

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986706778742972

Affiliations: Nesrina Imami, Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK

Publication date: November 1, 2006

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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