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Nucleic Acids Modulate Autoimmunity Through Nucleic-Acid-Specific Toll-Like Receptors

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Abstract:

Autoimmune diseases are believed to develop mainly from three factors comprising genetic predisposition, environmental factors and immune (dys-) regulation. In this context, specific nucleic acids of exogenous or endogenous origin that signal through nucleic acid-specific Toll-like receptors (TLRs) have gained much research attention. During ongoing autoimmune disease microbial nucleic acids contribute to flares of disease and its aggravation leading to end organ damage, through unfavourable immune modulation. Apart from exogenous sources, nucleic acid molecules of endogenous origin emerge as potential ligands for receptors of host defence, i.e. TLRs. Rapidly accumulating data on the role of nucleic acid-specific TLRs has not only provided insights about their pathogenic potential of endogenous nucleic acid molecules, but is also fuelling the development of novel immunotherapies.





Keywords: Autoimmunity; Immunoregulatory sequences; Inhibitory oligonucleotides; Toll-like receptors; lupus

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986706778521832

Affiliations: Medizinische Poliklinik der LMU, Pettenkoferstr. 8a, 80336 Munich, Germany.

Publication date: October 1, 2006

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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