Protein S-100B - A Prognostic Marker for Cerebral Damage

Authors: Stroick, Mark; Fatar, Marc; Ragoschke-Schumm, Andreas; Faβbender, Klaus; Bertsch, Thomas; Hennerici, Michael G.

Source: Current Medicinal Chemistry, Volume 13, Number 25, October 2006 , pp. 3053-3060(8)

Publisher: Bentham Science Publishers

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Abstract:

The assessment of S-100B in acute neurological disorders such as global hypoxia, ischaemic or haemorrhagic stroke and traumatic brain injury reflects severity of symptoms and outcome. However, the temporal profile of S-100B release depends on topography, intensity and pathophysiology of the damage e.g. immediate release after traumatic brain injury following the acute destruction of neuronal tissue or delayed release after ischaemic stroke in which gradual breakdown of the blood-brain barrier plays a crucial role.

In chronic brain diseases, knowledge about the clinical value of quantification of S-100B is scarce and further evaluations are needed. This review considers both conditions for S-100B measurement and illustrates advantages and limitations in comparison with clinical and neuroimaging data.

Keywords: S-100B; stroke; global hypoxia; traumatic brain injury

Document Type: Research article

Affiliations: 1: Department of Neurology,Universitatsklinikum Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer, 68135 Mannheim, Germany.

Publication date: 2006-10-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.