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Recent Progress in Medicinal Chemistry of D4 Agonists

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Abstract:

In the last decades, the physiological and pharmacological properties of dopamine receptors were controversial principally because of the lack of selective ligand for some receptor subtypes. Since 1997, some specific D4 agonists have been described and have allowed a therapeutic approach. We report here, compounds described as D4 agonist and when available the SAR. The major studies for physiological implications and their potential biological applications are also reported and principally their interest in erectile dysfunction.





Keywords: 3-phenylpiperidines; 4-phenylpiperazines; D4 agonist; penile erection

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986706778521841

Affiliations: Department of Medicinal Chemistry, Faculty of Pharmacy, 31 Avenue Monge, 37200 Tours, France.

Publication date: October 1, 2006

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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