Round and Round we Go: Cyclic Peptides in Disease

Authors: Katsara, Maria; Tselios, Theodore; Deraos, Spyros; Deraos, George; Matsoukas, Minos-Timotheos; Lazoura, Eliada; Matsoukas, John; Apostolopoulos, Vasso

Source: Current Medicinal Chemistry, Volume 13, Number 19, August 2006 , pp. 2221-2232(12)

Publisher: Bentham Science Publishers

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Abstract:

There is a need for novel drugs for the treatment of infectious diseases, autoimmunity and cancer. Cyclic peptides constitute a class of compounds that have made crucial contributions to the treatment of certain diseases. Penicillin, Vancomycin, Cyclosporin, the Echinocandins and Bleomycin are well-known cyclic peptides. Cyclic peptides, compared to linear peptides, have been considered to have greater potential as therapeutic agents due to their increased chemical and enzymatic stability, receptor selectively, and improved pharmacodynamic properties. They have been used as synthetic immunogens, transmembrane ion channels, antigens for Herpes Simplex Virus, potential immunotherapeutic vaccines for diabetes and Experimental Autoimmune Encephalomyelitis - an animal model of Multiple Sclerosis, as inhibitors against α-amylase and as protein stabilizers. Herein, we review important cyclic peptides as therapeutic agents in disease.

Keywords: Angiotensin II; Cyclic peptides; Gonadotropin Releasing Hormone; Myelin epitopes; Thrombin

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986706777935113

Affiliations: Burnet Institute at Austin, Immunology and Vaccine Laboratory, Studley Road, Heidelberg, VIC 3084, Australia.

Publication date: August 1, 2006

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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