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Bringing Kinases Into Focus: Efficient Drug Design Through the Use of Chemogenomic Toolkits

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Abstract:

The study of protein target families, as opposed to single targets, has become a very powerful tool in chemogenomics-led drug discovery. By integrating comprehensive chemoinformatics and bioinformatics databases with customised analytical tools, a 'Toolkit' approach for the target family is possible, thus allowing predictions of the ligand class, affinity, selectivity and likely off-target issues to be made for the guidance of the medicinal chemist. In this review, we highlight the development and application of the Toolkit approach to the protein kinase superfamily, drawing on examples from lead optimisation studies and the design of focused libraries for lead discovery.

Keywords: 2D-roadmap™; CDK2; CDK4; Chemogenomics; KSA; Kinome Similarity Analysis™; Toolkit; cyclin-dependent kinases; kinases; p38

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986706777452452

Affiliations: BioFocus, Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, UK.

Publication date: June 1, 2006

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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