Emerging Role of Intravascular Ultrasound in the Assessment of Experimental Anti-Atherosclerotic Therapies

Authors: Nicholls, Stephen J.; Sipahi, Ilke

Source: Current Medicinal Chemistry, Volume 13, Number 15, June 2006 , pp. 1727-1734(8)

Publisher: Bentham Science Publishers

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Abstract:

Intravascular ultrasound (IVUS) imaging within the coronary arteries has emerged as the gold standard for the quantitation of the extent of atherosclerosis plaque. Studies that have utilized IVUS have enhanced our understanding of the in vivo natural history of atherogenesis. As IVUS can be performed within the same coronary artery at different time points it has become an attractive tool for the assessment of the effect of experimental anti-atherosclerotic strategies on plaque burden. This review will review the evolution of IVUS as an imaging modality and highlight its use to assess a number of interventions that are directed at both modification of existing risk factors and novel targets that are thought to play a pivotal role in the pathogenesis of atheroma formation.

Keywords: Angiography; external elastic membrane (EEM); Plaque Progression; High density lipoprotein (HDL); acute coronary syndrome

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986706777452498

Affiliations: 1: Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Mail Code JJ-65, 9500 Euclid Avenue, Cleveland OH, 44195, USA.

Publication date: 2006-06-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.