Advance in Antitumor Agents Targeting Glutathione-S-Transferase
Abstract:Glutathione-S-transferases (GSTs; EC 184.108.40.206), a family of phase II detoxification enzymes, catalyze the conjugation of glutathione with broad substrates including chemotherapeutic agents, and are involved in cell protection against apoptotic signals by inhibiting the stress-signaling cascade mediated by ASK1 (Apoptosis signal-regulating kinase)-JNK (c-Jun N-terminal kinase). As GSTs are overexpressed in some malignant tumors, GSTs is a promising therapeutic target. This article reviews the progress in the development of GSTs inhibitors and GSTs activated prodrugs.
Document Type: Research Article
Affiliations: Department of Medicinal Chemistry, College of Pharmacy, Shandong University, Jinan, Shandong 250012, PR China.
Publication date: May 1, 2006
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