Skip to main content

Advance in Antitumor Agents Targeting Glutathione-S-Transferase

Buy Article:

$63.00 plus tax (Refund Policy)


Glutathione-S-transferases (GSTs; EC, a family of phase II detoxification enzymes, catalyze the conjugation of glutathione with broad substrates including chemotherapeutic agents, and are involved in cell protection against apoptotic signals by inhibiting the stress-signaling cascade mediated by ASK1 (Apoptosis signal-regulating kinase)-JNK (c-Jun N-terminal kinase). As GSTs are overexpressed in some malignant tumors, GSTs is a promising therapeutic target. This article reviews the progress in the development of GSTs inhibitors and GSTs activated prodrugs.

Keywords: Antitumor agents; Apoptosis; Drug-resistance; GST inhibitors; Glutathione-S-transferases; Prodrugs

Document Type: Research Article


Affiliations: Department of Medicinal Chemistry, College of Pharmacy, Shandong University, Jinan, Shandong 250012, PR China.

Publication date: May 1, 2006

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more