Antimicrobial Peptides with Unusual Amino Acid Compositions and Unusual Structures
Abstract:Antimicrobial peptides, which constitute an important component of innate immunity in animal and plant kingdom, are ubiquitously distributed in nature. However, they differ widely in their sizes, sequences and structures. On the basis of their structure they have been broadly classified into three classes: a) linear peptides with propensity for amphiphilic a-helical structure, b) peptides with β or αβ structure stabilized by different number of disulfide bridges and c) peptides with over-representation of certain amino acids or unusual structures. Although considerable amount of work has been done on peptides of all the three classes, recent reviews have emphasized on peptides belonging to the first two classes. The present review focuses on the peptides belonging to the third group. The antimicrobial peptides discussed in this article include aromatic amino acid-rich peptides, (Pro-Arg)-rich peptides, unusual defensins and defensin-like molecules, unusual antimicrobial peptides from amphibians, bacteriocins with unusual structure and anionic antimicrobial peptides.
Keywords: Anionic antimicrobial peptides; Aromatic amino acid-rich peptides; Bacteriocins with unusual structures; PR-rich peptides; Unusual antimicrobial peptides from amphibians; Unusual defensins and defensin-like peptides
Document Type: Research Article
Affiliations: R&D New Initiative, Panacea Biotec Ltd. B-1, Extn/G-3, Mohan Co-op Indl. Estate; Mathura Road, New Delhi 110 044, India.
Publication date: 2006-03-01
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.