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A Role for Leptin in the Systemic Inflammatory Response Syndrome (SIRS) and in Immune Response, an Update

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Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research revealed that leptin's biological action is not restricted to its effects on appetite and food intake, but instead has a much more pleiotropic character. There is now ample evidence that leptin has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review we have focused on the effects of leptin in the antigen-specific immunity and in the inflammatory effector system.

Keywords: CRH-knockout; DTH reaction; Septic Shock; leptin receptor; lymphocytes; pro-inflammatory mediators

Document Type: Research Article


Affiliations: Dept. of Pathology, Ghent University, De Pintelaan 185, 9000 Gent, Belgium.

Publication date: February 1, 2006

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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