Fluoroquinolones: An Important Class of Antibiotics Against Tuberculosis

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Abstract:

Tuberculosis (TB) is a global health problem due to the lack of new drugs in the market and also due to the advent of multidrug resistant strains (MDR). This disease affects around 8 million people and kills almost 3 million people each year and it is estimated that there are 1 billion infected with TB worldwide. Due to this problem fluoroquinolones have attracted much attention as the new class of anti TB drugs due to their fewer toxic side effects, improved pharmacokinetic properties and extensive and potent activity against Grampositive and Gram-negative bacteria, including resistant strains. In this present review we report fluoroquinolones as a promising new class of anti TB.

Keywords: Tuberculosis; antibiotics; fluoroquinolones

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986706775527965

Affiliations: Universidade Federal de Juiz de Fora - Departamento de Quimica, UFJF, 36036-330 Juiz de Fora - MG - Brazil.

Publication date: February 1, 2006

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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