5-Lipoxygenase, Leukotrienes Biosynthesis and Potential Antileukotrienic Agents

Authors: Jampilek, Josef; Dolezal, Martin; Opletalova, Veronika; Hartl, Jiri

Source: Current Medicinal Chemistry, Volume 13, Number 2, January 2006 , pp. 117-129(13)

Publisher: Bentham Science Publishers

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Abstract:

Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.

Keywords: 5-lipoxygenase; FLAP; LTA4-hydrolase; leukotrienes; antileukotrienic agents

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986706775197935

Affiliations: 1: Zentiva a.s., U kabelovny 130, 102 37 Prague, Czech Republic.

Publication date: 2006-01-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.