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Sol-gel Chemistry in Medicinal Science

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Abstract:

The sol-gel process is an inorganic polymerization process taking place in mild conditions, allowing the association of mineral phases with organic or biological systems. The possibility to immobilize drugs, enzymes, antibodies and even whole cells without loss of their biological activity led to the development of diagnostic tools, drug delivery carriers as well as new hosts for artificial organ design. These systems take profit from the wide variety of chemical compositions, dimensions and forms that can be achieved via sol-gel chemistry. Recent advances involve multifunctional "smart" devices combining biocompatibility, biological activity and stimuli-responsive materials. The design of such novel devices with significant added value when compared to current products is probably a key factor when foreseeing industrial developments of sol-gel materials in medicinal science.

Keywords: Sol-gel; artificial organs; biosensors; drug delivery; encapsulation; hybrid materials; silica

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986706789803044

Affiliations: Laboratoire de Chimie de la Matiere Condensee, CNRS-UMR 7574, Universite Pierre et Marie Curie, 75252 Paris cedex 05, France;

Publication date: January 1, 2006

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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