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Quorum Sensing Inhibition: Targeting Chemical Communication in Gramnegative Bacteria

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Abstract:

Quorum sensing (QS) systems comprise a new therapeutic target potentially substitutive or complementary to traditional antibiotic treatment of chronic diseases. One route to disrupt the previously established interrelationship between pathogenesis and QS is by blocking the dual functioning signal/receptor transcriptional regulator in some clinically relevant Gram-negative bacteria. The present review contains all reported compound types that are currently known to inhibit the QS transcriptional regulator in Gram-negative bacteria. These compounds are sub-divided into two main groups, one comprising structural analogs of the native signaling molecules and the other compounds lacking structural resemblance. Biological activity is rationalized on the basis of structure-activity relationships and structural insight into the target protein.

Keywords: Butenolides; CviR assays; Dihydroflustramine C; LuxR monitor system; autoinducers; ligand-based design

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/092986705774933425

Affiliations: Department of Natural Sciences, Bioorganic Chemistry Section, The Royal Danish Veterinary and Agricultural University, DK-1871 Frederiksberg C, Denmark.

Publication date: December 1, 2005

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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