Authors: Kostadinova, Radina; Wahli, Walter; Michalik, Liliane

Source: Current Medicinal Chemistry, Volume 12, Number 25, December 2005 , pp. 2995-3009(15)

Publisher: Bentham Science Publishers

Abstract:

The three isotypes of peroxisome proliferator-activated receptors (PPARs), PPARa, / and , are ligand-inducible transcription factors that belong to the nuclear hormone receptor family. PPARs are implicated in the control of inflammatory responses and in energy homeostasis and thus, can be defined as metabolic and anti-inflammatory transcription factors. They exert their anti-inflammatory effects by inhibiting the induction of pro-inflammatory cytokines, adhesion molecules and extracellular matrix proteins or by stimulating the production of anti-inflammatory molecules. Furthermore, PPARs modulate the proliferation, differentiation and survival of immune cells including macrophages, B cells and T cells. This review discusses the molecular mechanisms by which PPARs and their ligands modulate the inflammatory response. In addition, it presents recent developments implicating PPAR specific ligands in potential treatments of inflammationrelated diseases, such as atherosclerosis, inflammatory bowel diseases, Parkinson's and Alzheimer's diseases.

Keywords: peroxisome proliferator-activated receptors; transcription factors; molecular mechanisms; inflammatory cells; inflammatory diseases; atherosclerosis; fibrosis; cancer

Document Type: Review article

DOI: http://dx.doi.org/10.2174/092986705774462905

Affiliations: 1: Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH-1015 Lausanne, Switzerland.

Publication date: 2005-12-01

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• Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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