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Soluble Paramagnetic Chelates and Stabilized Colloidal Particle Solutions of Iron Oxides as Contrast Agents for Magnetic Resonance Imaging

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Abstract:

The development of contrast agents shortening the relaxation times of protons began more than 20 years ago in order to improve the capability of diagnosing disease by means of magnetic resonance imaging (MRI). A variety of extracellular and tissue specific contrast agents were developed based on two types of molecules. One type was related to soluble paramagnetic chelates and the other type to stabilized colloidal particle solutions of iron oxides. The chelate or metal complex of gadopentetate dimeglumine was the pioneering magnetic resonance (MR) contrast agent used in 1988. Chemical modifications of this chelate and the design of new chelates led to tissue or blood pool specificity in MRI. Similarly, modifications in coating materials and variations in size of iron oxide particles allowed for tissue specificity or blood pool properties in MRI. Both types of contrast agents offer excellent perspectives for clinical MRI and for molecular imaging.

Keywords: bloodpool contrast agents; contrast media; gadolinium chelate; hepatobiliary contrast agents; particles of iron oxide

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/092986705774462932

Affiliations: Department of Clinical Radiology, University of M√ľnster, Albert-Schweitzer-Str. 33, D - 48129 Munster, Germany.

Publication date: November 1, 2005

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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