Receptor Tyrosine Kinases as Targets for Anticancer Therapeutics

$63.10 plus tax (Refund Policy)

Buy Article:

Abstract:

Oncogenic conversion of receptor protein tyrosine kinases (RTK) is a frequent feature of malignant cells. This knowledge has fostered efforts to develop target-specific low molecular weight therapeutics able to obstruct RTK signalling. The clinical efficacy of the ABL- and KIT-inhibitors are paradigmatic of the power of this approach. Here, we focus on small-molecule inhibitors for RTKs involved in human cancer. In particular, we examine the KIT, MET and RET receptors that are targeted by genetic alterations in both sporadic and familial human tumours.

Keywords: germline; kinase; kit; met; oncogene; ret; thyroid; tyrosine

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867054367266

Affiliations: Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita' di Napoli “Federico II”, via S. Pansini 5, 80131 Napoli, Italy.

Publication date: July 1, 2005

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more