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Inhibition of P450 17 as a New Strategy for the Treatment of Prostate Cancer

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Abstract:

The cytochrome P450 monooxygenase enzyme system is involved in the synthesis and/or degradation of a large number of endogenous compounds and in the biotransformation of drugs and other xenobiotics. 17α-Hydroxylase-C17,20-lyase (P450 17, CYP 17) is the key enzyme of the androgen biosynthesis. As androgens have been implicated in the development and progression of prostate cancer, this enzyme has become a promising therapeutic target. This paper will review the possible approaches dealing with P450 17 inhibition as a chemotherapeutic strategy in the struggle against prostate cancer.

Keywords: abiraterone; androgen; cyp; hydroxylase-c; liarozole; lyase; non-steroidal inhibitors; prostate cancer; steroidal inhibitors

Document Type: Review Article

DOI: https://doi.org/10.2174/0929867054367185

Affiliations: Laboratoire de Stereochimie associe au CNRS (UMR CNRS 7509), Universite Louis Pasteur (ECPM), 25 rue Becquerel, F- 67087 Strasbourg Cedex 2, France.

Publication date: 2005-07-01

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