Design and Synthesis of Protein Superfamily-Targeted Chemical Libraries for Lead Identification and Optimization
Abstract:This review chronicles original literature dating back to 1992 outlining the applications of parallel synthesis and combinatorial chemistry to the synthesis of compound libraries focused towards specific superfamilies of molecular targets. Target families that have received significant literature coverage include kinases, proteases, nuclear hormone receptors and cell surface receptors, notably GPCRs.
Document Type: Review Article
Affiliations: Plramed Ltd., 957 Buckingham Avenue, Slough, Berkshire SL1 4NL, UK.
Publication date: 2005-06-01
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