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Design and Synthesis of Protein Superfamily-Targeted Chemical Libraries for Lead Identification and Optimization

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This review chronicles original literature dating back to 1992 outlining the applications of parallel synthesis and combinatorial chemistry to the synthesis of compound libraries focused towards specific superfamilies of molecular targets. Target families that have received significant literature coverage include kinases, proteases, nuclear hormone receptors and cell surface receptors, notably GPCRs.

Keywords: combinatorial; gpcr; kinase; nuclear hormone receptor; parallel; protease

Document Type: Review Article


Affiliations: Plramed Ltd., 957 Buckingham Avenue, Slough, Berkshire SL1 4NL, UK.

Publication date: 2005-06-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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