Post-assembly Peptide Modifications by Chemical Methods

Authors: Kotha Sambasivarao; Lahiri Kakali

Source: Current Medicinal Chemistry, Volume 12, Number 7, April 2005 , pp. 849-875(27)

Publisher: Bentham Science Publishers

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Abstract:

The demand for peptide drugs is increasing and in this context, “post-assembly (or posttranslational) peptide modification strategies” by chemical manipulation of intact oligo-peptides has provided several analogues. Compounds prepared by this method are useful therapeutic molecules for structure activity studies. Herein, we describe various chemical methods such as cross-coupling reactions, cycloaddition reactions, radical reactions and ring-closing metathesis reactions that are useful for posttranslational peptide modifications.

Keywords: sequencing; human genome; peptide; oxidation; biomimetic cyclization; crosscoupling reactions; photoaffinity

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929867053507333

Affiliations: 1: Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai-400 076, India.

Publication date: 2005-04-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.