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Post-assembly Peptide Modifications by Chemical Methods

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The demand for peptide drugs is increasing and in this context, “post-assembly (or posttranslational) peptide modification strategies” by chemical manipulation of intact oligo-peptides has provided several analogues. Compounds prepared by this method are useful therapeutic molecules for structure activity studies. Herein, we describe various chemical methods such as cross-coupling reactions, cycloaddition reactions, radical reactions and ring-closing metathesis reactions that are useful for posttranslational peptide modifications.

Keywords: biomimetic cyclization; crosscoupling reactions; human genome; oxidation; peptide; photoaffinity; sequencing

Document Type: Review Article


Affiliations: Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai-400 076, India.

Publication date: 2005-04-01

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