Gadolinium Meets Medicinal Chemistry: MRI Contrast Agent Development

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Abstract:

Magnetic resonance imaging (MRI) contrast agents are utilized adjunctively to enhance the contrast between normal and abnormal structures on MRI scans. Along with the rapid evolution of the field has come a new appreciation for the medicinal chemistry of this unique class of metallopharmaceuticals. The efficacy of MRI agents is a complex function of chemical, biophysical, and pharmacological properties, which must be married in a package of exquisite safety. This report illustrates the wide range of medicinal chemistry relevant to existing agents that are either approved or in clinical development, as well as concepts, which may result in exciting new pharmaceuticals in the future.

Keywords: contrast agents; extracellular contrast agents; gadolinium; liver contrast agents; mri; vascular contrast agents (blood pool contrast agents)

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867053507379

Affiliations: EPIX Pharmaceuticals, Inc.,67 Rogers Street, Cambridge, MA 02142-1118, USA.

Publication date: April 1, 2005

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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