Prenylated Flavonoids: Pharmacology and Biotechnology
Authors: Botta, Bruno; Vitali, Alberto; Menendez, Pilar; Misiti, Domenico; Monache, Giuliano D.
Source: Current Medicinal Chemistry, Volume 12, Number 6, March 2005 , pp. 713-739(27)
Publisher: Bentham Science Publishers
Abstract:Within the flavonoid class of natural products the prenylated sub-class is quite rich in structural variety and pharmacological activity. In the last twenty years a huge number of new structures has been reported, mostly from Leguminosae and Moraceae, with few coming from other genera. The presence, in different forms, of the isoprenoid chain can lead to impressive changes in biological activity, mostly attributed to an increased affinity for biological membranes and to an improved interaction with proteins. Molecules, such as xanthohumol and sophoraflavanone G, while being very structurally simple, show numerous pharmacological applications and are ideal candidates for SAR aimed to the discovery of new drugs.
Only recently the biogenesis of these compounds has been more extensively studied and much attention has been focused on the enzymes involved in the modification and transfer of the prenyl unit.
Document Type: Review Article
Affiliations: Chimica e Tecnologia delle Sostanze Biologicamente Attive, Universita “La Sapienza”, P.le Aldo Moro 5, 00185 Roma, Italy.
Publication date: March 2005
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.