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Transcription Factor Therapeutics: Long-shot or Lodestone

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Abstract:

Many drugs, both approved and in development, exert their effects through transcription factors. The complexity of the biology of transcriptional regulation, however, presents challenges to the effective design of therapies that directly target transcription factors. This review focuses on the different approaches that are currently pursued in therapeutics and drug discovery aimed at targeting transcription factors and signaling molecules, and their areas of effect in transcription factor biology. A relatively recent approach termed “transcription therapy” has been applied for a number of drugs in development, which may potentially provide a new avenue for targeting transcription factors for therapeutic purposes.

Keywords: drug discovery; gene networks; gene regulation; promoters; transcription factors

Document Type: Review Article

DOI: https://doi.org/10.2174/0929867053202197

Affiliations: Institute for Transcriptional Informatics, P.O. Box. 2556, Pittsburgh, PA. 15230-2556, USA.

Publication date: 2005-03-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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