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Betulinic Acid and Its Derivatives: A Review on their Biological Properties

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Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human immunodeficiency virus (HIV), antibacterial, antimalarial, antiinflammatory, anthelmintic and antioxidant properties. This article reports a survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990's to the beginning of 2003. A broad range of medical and pharmaceutical disciplines are covered, including a brief introduction about discovery, phytochemical aspects, organic synthesis, anti-HIV and cytotoxic mechanisms of action. Various structural modifications carried out and their biological and pharmacokinetic profiles are also incorporated.

Keywords: anti-hiv derivatives; anti-hiv mechanism; anticancer derivatives; anticancer mechanism; antiinflammatory; antimalarial; betulinic acid; biotransformation

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867053202214

Affiliations: Pharmacy Department, Birla Institute of Technology & Science, Pilani-333031, INDIA.

Publication date: March 1, 2005

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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