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Biorational Approaches for Insect Control by Enzymatic Inhibition

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Abstract:

Conventional insecticides are highly toxic to many living organisms as well as to the environment; consequently, new biorational and more specific approaches to pest control have been developed. In this paper, we present an update of those approaches resulting from studies on inhibition of enzymes involved in key processes of insects life, particularly growth, molting and development of larvae and intraspecific communication of adults. The enzymes covered include pheromone degrading enzymes, pheromone biosynthetic enzymes, oxidoreductases, juvenile hormones, juvenile hormone epoxide hydrolases, proteases, molting hormones and phenoloxidases. Although these approaches refer to control of insect pests, many of them can be in principle also considered suitable for medicinal chemistry studies, since the mechanism of action of these inhibitors on related enzymes is quite similar, if not equal, in both fields.

Keywords: enzyme inhibitors; juvenile hormones; molting hormones; oxidoreductases; pest control; phenoloxidases; pheromone biosynthetic enzymes; pheromone degrading enzymes; proteases

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867053363126

Affiliations: Department of Biological Organic Chemistry, IIQAB (CSIC), Jordi Girona 18-26. 08034 Barcelona, Spain.

Publication date: February 1, 2005

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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