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Biologically Active Quassinoids and Their Chemistry: Potential Leads for Drug Design

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Abstract:

Quassinoids are highly oxygenated triterpenes, which were isolated as bitter principles from the plants of Simaroubaceae family. Their synthesis has attracted much attention because of the wide spectrum of their biological properties. The most prevalent quassinoids have C-20 picrasane skeleton, some known as bruceolides as they were isolated from the genus Brucea, which showed marked antileukemic and antimalarial activities.

Keywords: antileukemic and antimalarial activities; biological activities; quassinoids; sar; semi-synthesis; total synthesis

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867053363351

Affiliations: Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, B. C., V6T1Z3, Canada.

Publication date: January 1, 2005

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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