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Oligonucleotides and Oligonucleotide Conjugates: A New Approach for Cancer Treatment

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Abstract:

In this account we summarise recent studies on oligonucleotides and oligonucleotide derivatives and their utilisation in antigene, antisense and decoy approaches, with particular attention to peptide nucleic acids, locked nucleic acids and oligonucleotide conjugates, the most promising compounds in this field.

Keywords: Rnase; antisense oligonucleotides; gene-directed therapy; hybridisation; mrna

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867053363603

Affiliations: Dipartimento di Scienze Farmaceutiche, Universita di Trieste, Piazzale Europa.

Publication date: January 1, 2005

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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