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Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design

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This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds.

Keywords: antagonist; hplc; isosterism; lead compound; pharmacodynamic; pharmacokinetic; prostaglandin-h synthase-2 (pghs-

Document Type: Review Article


Affiliations: Laboratorio de Avaliacao e Sintese de Substancias Bioativas (LASSBio), Faculdade de Farmacia, Universidade Federal do Rio de Janeiro. CCS, Cidade Universitaria, CP 68.006, 21944-190, Rio de Janeiro, R.J., Brazil.

Publication date: 2005-01-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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