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Protein Tyrosine Phosphatases and their Inhibitors

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Abstract:

Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.

Keywords: cellular signaling; diseases; inhibitors; ptps; sar; therapeutics/drugs

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867053363504

Affiliations: Department of Chemistry,National Central University, Chung Li, Taiwan 32054, Republc of China.

Publication date: January 1, 2005

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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