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Haemoglobinopathy in Pregnancy: Diagnosis and Treatment

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Abstract:

Haemoglobinopathies differ in geographic prevalence but together are amongst the most common genetic disorders worldwide. Despite huge diagnostic progress, therapeutic options remain limited, with many treatments still at the experimental stage, no more so than in pregnancy: not only does the presence of a fetus subject treatments to greater limitations, but also any worsening of the anaemia as pregnancy progresses results in higher fetomaternal morbidity and mortality. Anaemia weakens the response to peripartum blood loss, with the risk of postpartum complications. Until recently the standard conventional therapy for severe anaemia was (repeated) blood transfusion, with its well-known risks. Recombinant human erythropoietin (rhEPO) can induce fetal haemoglobin and is a safer, if less immediately effective, alternative for the correction of anaemia in pregnant patients with haemoglobinopathy.

Keywords: anaemia; haemoglobin; haemoglobinopathy; pregnancy; recombinant human erythropoietin

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867043364180

Affiliations: Perinatal Physiology Research Unit, Department of Obstetrics & Gynaecology, Zurich University Hospital, Frauenklinikstrasse 10, CH-8091 Zurich, Switzerland.

Publication date: November 1, 2004

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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