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Recent Advances in 4'-Thionucleosides as Potential Antiviral and Antitumor Agents

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Abstract:

The classical 4'-oxonucleoside analogs exhibit interesting biological activities such as antibiotic, antiviral and antitumor, which are believed to be the result of inhibition of the viral or cellular DNA or RNA polymerase after being converted to their corresponding 5'-triphosphates. However, the activity of 4'- oxonucleosides were limited by their susceptibility to degradation by nucleoside phosphorylases or acid hydrolysis. This aspect called for the chemical modification of the carbohydrate portion. This compulsion led to two kinds of strategies; (1) replacement of the 4'-oxygen by the methylene group - carbocyclic nucleosides; (2) replacement of the 4' oxygen by sulphur-4'-thionucleosides. This group has also conferred the resistance to the nucleoside cleavage. Although, there were some pioneering work on 4'-thionucleosides in 1960s and 1970s, the interest in this group of compounds was rekindled by the antiviral activities of 2'-deoxy-4'- thionucleosides reported independently by Secrist et al. and Walker et al. Subsequent contributions by the other authors, enhanced its standing as an important class of antiviral agents. Following is a reasonably exhaustive account of this class of compounds reported after 1990.

Keywords: 4'-thionucleoside; antitumor; antiviral; dimesylate; dithioacetal; participation of sulfur

Document Type: Review Article

DOI: https://doi.org/10.2174/0929867043364478

Affiliations: Laboratory of Medicinal Chemistry, Ewha Womans University, Seoul 120-750, Korea.

Publication date: 2004-10-01

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