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Structural Aspects of Carbohydrates and the Relation with their Biological Properties

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Structural diversity of carbohydrates plays a crucial role in their large variety of roles in biological systems. This paper focuses on aspects of structure and biological functions of three classes of carbohydrates, N-linked oligosaccharides, blood group oligosaccharides and glycosaminoglycans. Conformations and dynamics in solution, as well as structure of protein-carbohydrate complexes are discussed. A short overview also describes theoretical and experimental methodologies that are used in current glycobiological research, particularly high-resolution NMR spectroscopy, X-ray crystallography and methods of computational chemistry.
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Keywords: NMR spectroscopy; carbohydrates; crystallography; oligosaccharides

Document Type: Review Article

Affiliations: Institute of Chemistry, Slovak Academy of Sciences,845 38 Bratislava, Slovakia.

Publication date: 2004-10-01

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