Structural Aspects of Carbohydrates and the Relation with their Biological Properties

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Abstract:

Structural diversity of carbohydrates plays a crucial role in their large variety of roles in biological systems. This paper focuses on aspects of structure and biological functions of three classes of carbohydrates, N-linked oligosaccharides, blood group oligosaccharides and glycosaminoglycans. Conformations and dynamics in solution, as well as structure of protein-carbohydrate complexes are discussed. A short overview also describes theoretical and experimental methodologies that are used in current glycobiological research, particularly high-resolution NMR spectroscopy, X-ray crystallography and methods of computational chemistry.

Keywords: NMR spectroscopy; carbohydrates; crystallography; oligosaccharides

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867043364414

Affiliations: Institute of Chemistry, Slovak Academy of Sciences,845 38 Bratislava, Slovakia.

Publication date: October 1, 2004

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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