Lipid, Sugar and Liposaccharide Based Delivery Systems 2

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Abstract:

The vast majority of biologically active compounds will never be considered as potential drugs due to inherently poor bioavailability. This review discusses the progress in the development of chemical systems to improve the metabolic stability, absorption and physicochemical properties of potential drugs. Delivery systems that involve the conjugation of lipid and / or sugar moieties are highlighted, as well as novel methods of conjugation of these groups to drugs. The use of sugar molecules to target drugs to particular organs or cells is also discussed, as is the use of lipids in the growing area of gene delivery. This is an update of a previous review [1].

Keywords: drug delivery; lipid; liposaccharide; sugar

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867043364621

Affiliations: School of Molecular and Microbial Sciences, The University of Queensland, St. Lucia, Queensland 4072, Australia.

Publication date: September 1, 2004

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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