P-selectin Cell Adhesion Molecule in Inflammation, Thrombosis, Cancer Growth and Metastasis

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Abstract:

P-selectin (CD62P) is a member of the selectin family of cell adhesion molecules. It is expressed on stimulated endothelial cells and activated platelets and mediates leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. It also mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. Using P-selectin knockout mice, the importance of P-selectin-mediated cell adhesive interactions in the pathogeneses of inflammation, thrombosis, growth and metastasis of cancers has been clearly demonstrated. Here we will summarize the current knowledge and highlight the important progress in the biomedical research of P-selectin biology, providing a suitable target for therapeutic interventions developed through both experimental and bioinformatic approaches.

Keywords: cancer cell; cancer growth and metastasis; cell adhesion molecule; endothelial cell; inflammation; leukocyte; platelet; selectin; thrombosis

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867043364720

Affiliations: Vascular Biology Center and Division of Hematology, Oncology and Transplantation, University of Minnesota Medical School, Minneapolis, MN 55455, USA

Publication date: August 1, 2004

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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