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Structural Bioinformatics and its Impact to Biomedical Science

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Abstract:

During the last two decades, the number of sequence-known proteins has increased rapidly. In contrast, the corresponding increment for structure-known proteins is much slower. The unbalanced situation has critically limited our ability to understand the molecular mechanism of proteins and conduct structurebased drug design by timely using the updated information of newly found sequences. Therefore, it is highly desired to develop an automated method for fast deriving the 3D (3-dimensional) structure of a protein from its sequence. Under such a circumstance, the structural bioinformatics was emerging naturally as the time required. In this review, three main strategies developed in structural bioinformatics, i.e., pure energetic approach, heuristic approach, and homology modeling approach, as well as their underlying principles, are briefly introduced. Meanwhile, a series of demonstrations are presented to show how the structural bioinformatics has been applied to timely derive the 3D structures of some functionally important proteins, helping to understand their action mechanisms and stimulating the course of drug discovery. Also, the limitation of these approaches and the future challenges of structural bioinformatics are briefly addressed.

Keywords: adhesion proteins; antifreeze protein; bovine somatotropin; caspase; complement control protein; gfat; ion-channels; nachr; neuronal kinase; secretase & zymogen

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867043364667

Affiliations: Gordon Life Science Institute, California 92130, USA

Publication date: August 1, 2004

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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