Herb-Drug Interactions: An Evidence Based Approach

Authors: Coxeter P.D.; McLachlan A.J.; Duke C.C.; Roufogalis B.D.

Source: Current Medicinal Chemistry, Volume 11, Number 11, June 2004 , pp. 1513-1525(13)

Publisher: Bentham Science Publishers

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Abstract:

The increasing use of herbal medicinal products (HMPs) in the community where people are also receiving prescription medicines suggests that adverse herb-drug interactions may be of significant public health consequence. The evidence available to guide practitioners in decision making is complex and consists of a range of sources including adverse event database entries, spontaneous or case reports, in vivo and in vitro drug metabolism studies, and in vivo drug interaction studies in healthy subjects and patients. In the absence of further rigorous studies to assess the clinical significance of herb-drug interactions, an evidencebased appraisal of the current literature is essential to guide practitioners involved in patient care.

Keywords: herb-drug interactions; pharmacokinetics; pharmacodynamics; hypericum perforatum; panax ginseng; ginkgobiloba; glycyrrhiza glabra

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929867043365198

Affiliations: 1: Faculty of Pharmacy, Building A15, The University of Sydney, NSW 2006, Australia

Publication date: 2004-06-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.