Authors: Maurya R.; Srivastava S.; Kulshreshta D.K.; Gupta C.M.

Source: Current Medicinal Chemistry, Volume 11, Number 11, June 2004 , pp. 1431-1450(20)

Publisher: Bentham Science Publishers

Abstract:

Plants have been used worldwide for treatment of various human ailments since antiquity. Their use is still quite prevalent in developing countries in the form of traditional / folkloric system of medicine. Intensive chemical and pharmacological studies on traditional / folkloric medicinal plants during the last 5 decades have led to the validation of traditional claims in many cases and facilitated identification of their active principles. The active principles have provided leads in the development of several life saving drugs, which are in clinical use today. A large number of these plants are used for birth control in different countries. The present review has, therefore, been planned to provide an account of the investigations carried out on traditional / folkloric plants used for fertility regulation. The status of scientific validations of their antifertility potential and identification of active principles during the last 28 years are discussed. The literature survey shows that approximately 318 different plants are in traditional / folkloric use worldwide, of which 227 plants are of Indian origin. So far, 74 plants have been screened for their anti-fertility potential, 48 of them have been found to be effective. Active principles of about 15 plants have been identified during the period under review.

Keywords: traditional; toxicology; folklore; anti-fertility; anti-implation; abortifacient

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929867043365215

Affiliations: 1: Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India

Publication date: 2004-06-01

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• Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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