The Vif protein of Human Immunodeficiency Virus Type 1 (HIV-1): Enigmas and Solutions [General Articles]

Authors: Baraz, Lea; Kotler, Moshe

Source: Current Medicinal Chemistry, Volume 11, Number 2, January 2004 , pp. 221-231(11)

Publisher: Bentham Science Publishers

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Abstract:

HIV-1 and other complex retroviruses express six auxiliary genes in addition to the canonical retroviral genes, gag, pol and env. Vif (virion infectivity factor) protein is absolutely essential for productive HIV-1 infection of peripheral blood lymphocytes and macrophages, the two major HIV-1 target cells in vivo. However, Vif is not required for production of infectious particles in several human cell lines. In spite of the prominent phenotype of Vif mutations, the mechanism of its action remains unknown. During the last decade several models were suggested to explain the mechanism of Vif activity. One view holds that Vif is active in virions after budding or after entry into target cells during the early stages of HIV-1 replications. The second view places the action of Vif at the late stage of HIV-1 replication in virus producing cells, which affects the production of infectious virus. According to this view, Vif either compensates the cell factor required for production of infectious virus, or alternatively, it neutralizes a cell factor, which prevents the production of infectious particles in these cells.

This review is addressed to summarize the models envisioned to explain Vif activities. The findings described here, that Vif interacts with viral and cellular components, elaborates the importance of Vif as a novel target for developing anti HIV-1 drugs.

Keywords: cellular anti hiv-1 factor; drug resistance; hiv-1; hiv-1 protease; peptide-mapping; protease inhibitors; vif

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867043456124

Affiliations: Department of Pathology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

Publication date: January 1, 2004

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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