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Conception and Realization of a Non-Cationic Non-Viral DNA Vector

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Abstract:

Cationic non-viral DNA vectors are very successful in in vitro transfections but less efficient in in vivo tests. This seems mainly due to the cationic nature of the molecules used to complex DNA. In this article, we describe the design and the route towards the realization of a non-viral non-cationic vector. The strategy follows three steps: first, the incorporation of DNA to a lamellar phase; second, the making of multilamellar vesicles containing a high loading of DNA by shearing the lamellar phase and, finally, the grafting of peptides onto the surface of the vesicles to target a specific receptor on the cells. Throughout this process, we had to overcome many obstacles; this review describes the present state of our work and summarizes the remaining steps.

Keywords: adhesion; dna; formulation; gene therapy; phase diagram; phospholipids; synthetic vector; x-ray

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867043456133

Affiliations: Centre de recherche Paul- Pascal, CNRS Ave Schweitzer, 33600, Pessac, France.

Publication date: January 1, 2004

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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