Amyloid β-Peptide [1-42]-Associated Free Radical-Induced Oxidative Stress And Neurodegeneration in Alzheimer's Disease Brain: Mechanisms and Consequences
Abstract:In addition to synapse loss, neurofibrillary tangles, and neurodegeneration, oxidative stress and amyloid β-peptide [Aβ] deposition are hallmarks of Alzheimer's disease [AD] brain. Our laboratory coupled these two characteristics of AD into a comprehensive model to account for the synapse loss and neurodegeneration in AD brain. This model combines much of the extant studies on AD and is based on oxidative stress associated with amyloid β-peptide. This review presents evidence in support of this model and provides insight into the molecular basis of this devastating dementing disorder.
Document Type: Review Article
Affiliations: Department of Chemistry; Center of Membrane Sciences; and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506 USA.
Publication date: December 1, 2003
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