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[General Articles] Aurones: A Subclass of Flavones with Promising Biological Potential

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Abstract:

Aurones [2-benzylidenebenzofuran-3(2H)-ones] are the secondary metabolites natural compounds belong to the flavonoids family, and structurally are the isomers of flavones, widely present in fruits and flowers where they play significant role in the pigmentation of the part of plant in which they occur. Literature survey clearly indicates that flavones, chalcones, flavonols and isoflavones have been studied largely for their therapeutical potential. Somehow, aurones still are less studied and it is only recently that these compounds have begun to be investigated.

In this review, we report the recent advances made on the therapeutical potential of aurones in different biological areas. Their synthesis, structure-activity relationships, the importance of the substitution pattern will also be discussed. Finally, some aspects regarding the possible development of aurones will be highlighted briefly.

Keywords: 2-benzylidenebenzofuran-3(2h)-ones; aurones; biological activities; sar; synthesis

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867033456468

Affiliations: Laboratoire de Pharmacognosie, Departement de Pharmacochimie Moleculaire, Faculte de Pharmacie de Grenoble, 38706 La Tronche, France.

Publication date: December 1, 2003

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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