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Microwave-Assisted Polymer-Supported Combinatorial Synthesis

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Lead identification and optimization is always a challenge to the medicinal chemists in drug discovery. Numbers of simple to complex and smaller to bigger organic compounds are prepared to meet the screening purpose of biological targets. Conventional solution phase synthetic methodologies are lacking the speed to run along with the need of medicinally interesting compounds due to their long reaction time, tedious work-up and purification problems. Alternatively opted polymersupported synthesis of combinatorial libraries has been emerged as a promising tool in generating large numbers of structurally diverse molecules in a manner rapidand parallel. Microwave-assisted solid / liquid phase combinatorial synthetic techniques have been proved efficient in reducing the reaction time from days & hours to minutes & seconds and more promisingly to produce improved yields with high purities. This review briefs about the theory behind microwave chemical technology and glimpses of recent advancements in its application on polymer supported combinatorial synthesis.

Keywords: combinatorial libraries; combinatorial synthesis; liquid phase combinatorial synthesis; microwave-assisted; polymer supported combinatorial synthesis; polymer-supported; synthetic methodologies

Document Type: Review Article


Affiliations: Laboratory of Combinatorial Drug Discovery, Department of Chemistry, National Dong Hwa University, Shou-Feng, Hualien 974, Taiwan.

Publication date: November 1, 2003

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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