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The Chemistry and Biochemistry of Spiraea japonica Complex

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The characteristic components of Spiraea japonica complex, which consists of seven varieties, are the hetisine- and atisine-type diterpene alkaloids, and the atisanetype diterpenes. From this complex, 20 hetisines, 37 atisines and 7 diterpenes were isolated during 1964-2001, including the observations of the isomerization of spiraea diterpene alkaloids having the oxazolidine ring and the interconversion of the oxazolidine rings, the configuration of the oxygen substitution at C-15 of the atisinetype alkaloids, and the interconversion relationship between the two main subtypes of the hetisine-type alkaloids. The chemotaxonomy based on structures of the reported diterpene alkaloids were suggested. The studies on the anti-inflammation, anti-platelet aggregation and neuroprotective bioactivities of the alkaloids from S. japonica var. acuta were reviewed as well.

Keywords: anti-inflammation; anti-platelet aggregation; atisane; atisine; chemotaxonomy; diterpene alkaloids; diterpenes; hetisine; neuroprotection; spiraea japonica

Document Type: Review Article


Affiliations: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kuming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming, Yunnan 650204, China.

Publication date: November 1, 2003

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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