Gene Regulation in Cancer Gene Therapy Strategies

Authors: Scanlon Ian; Lehouritis Panos; Niculescu-Duvaz Ion; Marais Richard; Springer Caroline J.

Source: Current Medicinal Chemistry, Volume 10, Number 20, October 2003 , pp. 2175-2184(10)

Publisher: Bentham Science Publishers

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Abstract:

Regulation of expression in gene therapy is considered to be a very desirable goal, preventing toxic effects and improving biological efficacy. A variety of systems have been reported in an ever widening range of applications, this paper describes these systems with specific reference to cancer gene therapy.

Keywords: transcriptional control; regulated expression; gdept; suicide gene

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929867033456837

Affiliations: 1: Cancer Research UK Centre for Cancer Therapeutics at the Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG; UK

Publication date: 2003-10-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.