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Coenzyme Q10 in Neurodegenerative Diseases

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Abstract:

Coenzyme Q10 (ubiquinone), which serves as the electron acceptor for complexes I and II of the mitochondrial electron transport chain and also acts as an antioxidant, has the potential to be a beneficial agent in neurodegenerative diseases in which there is impaired mitochondrial function and / or excessive oxidative damage. Substantial data have accumulated to implicate these processes in the pathogenesis in certain neurodegenerative disorders, including Parkinson's disease, Huntington's disease and Friedreich's ataxia. Although no study to date has unequivocally demonstrated that coenzyme Q10 can slow the progression of a neurodegenerative disease, recent clinical trials in these three disorders suggest that supplemental coenzyme Q10 can slow the functional decline in these disorders, particularly Parkinson's disease.

Keywords: antioxidant; coenzyme; mitochondria; neurodegeneration

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867033456882

Affiliations: Department of Neurosciences, 0662, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0662, USA.

Publication date: October 1, 2003

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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