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Mitochondrial Lipids as Apoptosis Regulators

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Abstract:

Mitochondria are key players in fundamental processes such as energy production and adaptive responses to cellular stress, including apoptosis. Mitochondrial membranes may undergo permeabilization when perturbed by a number of intracellular stress mediators, and consequently may allow the release of intramitochondrial proteins. This event triggers and amplifies the cellular apoptotic program, provided sufficient energy is available. Mitochondrial membranes are therefore both targets and regulators of intracellular pathways controlling cell fate. Evidence is emerging that the integration and biological outcome of these pathways might be critically dependent on the unique lipid composition of mitochondrial membranes.

Keywords: apoptosis; cardiolipin; ceramide; lipids; mitochondria

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867033457188

Affiliations: Department of Experimental Medicine and Biochemical Sciences, University “Tor Vergata”. Via Montpellier, 1. 00133 Rome, Italy.

Publication date: August 1, 2003

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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