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Bcl-2-Related Proteins as Drug Targets

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Abstract:

The Bcl-2 family of proteins provide the most unambiguous link between mitochondrial functions and apoptosis, as their only (or principal) functions appear to be as regulators of this cell death pathway. Rational drug design to manipulate the functions of these proteins has been hampered by the lack of a clear understanding of a biochemical or molecular function, with disruption of intra-family protein-protein interactions as the only known, but daunting, objective. There has been substantial progress in this task using molecular modeling and drug leads. The prospects are also good for development of chemical tools for functional analysis of the Bcl-2 proteins.

Keywords: apoptosis; bcl-2 family; bcl-2 proteins; bcl-2-related proteins; chemical tools; intra-family protein-protein

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867033457241

Affiliations: Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Publication date: August 1, 2003

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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