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Beta-propellers: Associated Functions and their Role in Human Diseases

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The β-propeller fold appears as a very fascinating architecture based on four-stranded antiparallel and twisted β-sheets, radially arranged around a central tunnel. Similar to the α / β-barrel (TIM-barrel) fold, the β-propeller has a wide range of different functions, and is gaining substantial attention. Some proteins containing β-propeller domains have been implicated in the pathogenesis of a variety of diseases such as cancer, Alzheimer, Huntington, arthritis, familial hypercholesterolemia, retinitis pigmentosa, osteogenesis, hypertension, and microbial and viral infections. This article reviews some aspects of 3D structure, amino acids sequence regularities, and biological functions of the proteins containing β-propeller domains. Major emphasis has been laid on β-propellers whose functions are associated to human diseases. Recent research efforts reported in the fields of protein engineering, drug design, and protein structure-function relationship studies, concerning the β-propeller architecture, have also been discussed.

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Keywords: drug design; protein engineering; sequence repeats; sequence-structure-function relationship; thermodynamic stability

Document Type: Review Article

Publication date: 2003-03-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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