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Structure-Activity Relationships in The Acronycine Series

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Abstract:

Acronycine is active against a broad spectrum of solid tumors. Structure activity relationships demonstrated the crucial role of the 1,2-double bond. A hypothesis of bioactivation into 1,2-epoxide led to the development of a series of 1,2- dihydroxy-1,2-dihydroacronycine and 1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine diesters that exhibited an increased potency when compared with the parent compound.

Keywords: acronycine; antitumor activity; catalytic osmic oxidation; cytotoxic activity; enlarged spectrum; increased potency; murine leukemia cell line; solid tumors

Document Type: Review Article

DOI: https://doi.org/10.2174/0929867023369213

Publication date: 2002-09-01

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