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Crystal Structures of Acridines Complexed with Nucleic Acids

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Acridines have been used as chemotherapeutic agents against bacteria, protozoa and fungi, and they now find important use as anticancer drugs. There is a paucity of crystal structures of acridine-DNA complexes above the dinucleotide level, but recent structures of acridinecarboxamide topoisomerase II poisons complexed to hexanucleotides have allowed a molecular rationalization of their structure-activity relationships for cytotoxicity and for their kinetics of DNA binding.
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Keywords: DNA; acridine-4-carboxamides; acridines; complexes; crystal structures; nucleic acids

Document Type: Review Article

Publication date: 01 September 2002

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